Plant Transcription Factor Database
Previous version: v3.0
Fragaria x ananassa
M-type_MADS Family
Species TF ID Description
FANhyb_icon00000192_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00002198_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00004089_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00005241_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00008197_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00011557_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00012668_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00015119_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00040879_a.1.g00001.1M-type_MADS family protein
FANhyb_icon00050360_a.1.g00001.1M-type_MADS family protein
FANhyb_rscf00000009.1.g00018.1M-type_MADS family protein
FANhyb_rscf00000023.1.g00006.1M-type_MADS family protein
FANhyb_rscf00000023.1.g00007.1M-type_MADS family protein
FANhyb_rscf00000030.1.g00023.1M-type_MADS family protein
FANhyb_rscf00000038.1.g00016.1M-type_MADS family protein
FANhyb_rscf00000038.1.g00023.1M-type_MADS family protein
FANhyb_rscf00000042.1.g00005.1M-type_MADS family protein
FANhyb_rscf00000071.1.g00010.1M-type_MADS family protein
FANhyb_rscf00000076.1.g00014.1M-type_MADS family protein
FANhyb_rscf00000173.1.g00002.1M-type_MADS family protein
FANhyb_rscf00000215.1.g00002.1M-type_MADS family protein
FANhyb_rscf00000265.1.g00012.1M-type_MADS family protein
FANhyb_rscf00000314.1.g00016.1M-type_MADS family protein
FANhyb_rscf00000399.1.g00012.1M-type_MADS family protein
FANhyb_rscf00000415.1.g00010.1M-type_MADS family protein
FANhyb_rscf00000441.1.g00001.1M-type_MADS family protein
FANhyb_rscf00000519.1.g00003.1M-type_MADS family protein
FANhyb_rscf00000532.1.g00010.1M-type_MADS family protein
FANhyb_rscf00000801.1.g00001.1M-type_MADS family protein
FANhyb_rscf00001026.1.g00001.1M-type_MADS family protein
FANhyb_rscf00001234.1.g00003.1M-type_MADS family protein
FANhyb_rscf00001300.1.g00004.1M-type_MADS family protein
FANhyb_rscf00001794.1.g00003.1M-type_MADS family protein
FANhyb_rscf00002566.1.g00002.1M-type_MADS family protein
FANhyb_rscf00002649.1.g00003.1M-type_MADS family protein
FANhyb_rscf00003249.1.g00002.1M-type_MADS family protein
FANhyb_rscf00004091.1.g00001.1M-type_MADS family protein
FANhyb_rscf00004505.1.g00002.1M-type_MADS family protein
FANhyb_rscf00004856.1.g00002.1M-type_MADS family protein
FANhyb_rscf00006321.1.g00001.1M-type_MADS family protein
FANhyb_rscf00007245.1.g00001.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513